Refaquin Hydroquinone 4% Tretinoin Fluocinolone Acetonide


Hydroquinone is classified therapeutically as a depigmenting agent. Tretinoin is classified therapeutically as a keratolytic. Fluocinolone Acetonide is classified therapeutically as an anti-inflammatory.

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Refaquin Hydroquinone Tretinoin Fluocinolone Acetonide

Hydroquinone 4%, Tretinoin 0.05%, Fluocinolone acetonide 0.01%

Refaquin cream is indicated for the short-term treatment of moderate to severe of the face, in the presence of measures for sun avoidance, including the use of sunscreens. Refaquin cream, a combination drug product containing corticosteroid, retinoid, and bleaching agent, is not indicated for the maintenance treatment of melasma. The safety and efficacy of Refaquin cream in the treatment of hyperpigmentation conditions other than melasma of the face have not been studied.

Tube, 15 g


  • Refaquin cream should be applied once daily at night. It should be applied at least 30 minutes before bedtime.
    Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry.
  • Apply a thin film of the cream to the hyperpigmented areas of melasma.
  • The application of Refaquin cream should be kept away from the eyes, nose, or angles of the mouth.
  • Not using more often than prescribed. Do not use occlusive dressing. If local irritation persists or becomes severe, the application of the medication should be discontinued, and the health care provider consulted.
  • During the day, use a sunscreen of SPF 30 or greater and wear protective clothing such as the use of a hat.
    Patients may use moisturizers and/or cosmetics during the day.
  • Therapeutic effects may be observed as early as 4 weeks.

PT. Surya Dermanto Medica Laboratories
Surabaya, Indonesia

Weight 100 g
  1. Jenna Mahanay (verified owner)

    This product is definitely giving my skin a more even, brighter tone. There is some peeling in the days following applications but I know that means it’s working. You definitely want to moisturize when using this product. The price is great! I’m purchasing multiple tubes this time!

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